The lands on the east of African continent are among the most important regions paid attention to by the Muslims and, including the Shiites, from the early years of Islam. The Muslim emigrants gradually presented Islam to the people of these regions, who converted to Islam and experienced various evolutions in the course of centuries up to now. The Shiism has as a long history as Islam itself in Tanzania, and the emigrant Twelver Shiites in Tanzania – with their background in Islamic India – played, as the emigrants native to the east of Africa, an important and decisive role in history and culture of Shiism in Tanzania. They made use of the appropriate climatic and economic conditions of the region to firmly establish their religious, cultural, and social status, be strongly influential in various domains where they lived, and be the most important factor for diffusing and promoting Shiism among the native black people in Tanzania. The writer of the present article went among the Shiites of Tanzania and Zanzibar to conduct a field study to recall the glorious history of Shiims in these regions and investigate the present situation of today’s Shiites with an emphasis on the role of cultural and educational institutes of Twelver Khoja Shiites in revival of Islam.