The present study aims at investigating the reasons for Shiite-phobia and the ways to confront it. The main question of the study is as follows: “what is the reason for Shiite-phobia and what are the ways to confront it?” to answer the question, the present study was conducted in a descriptive explanatory way. Based on the findings, the enemy’s Shiite-phobia started with Islamic revolution of Iran; and the reasons are as follows: the Shiite’s rich and dynamic culture, the Shiite’s geo-politic situation, the Shiite’s God-centrism thought as opposed to the Western humanitarianism, the Shiites’ victories and strength in confronting enemies, the possibility to expand the Islamic revolution and to awaken the Muslims all over the world, as well as the idea of clash of civilizations and the Westerner’s concern about the Shiite’s victory in such a war. To confront this psychological phenomenon, the states, media and the elites of the Shiite societies must take effective measures to remove the consequences of this psychological invasion.